DNA-Encoded Library (DEL) technology has enabled significant advances in hit identification by enabling efficient testing of combinatorially-generated molecular libraries. DEL screens measure protein binding affinity though sequencing reads of molecules tagged with unique DNA-barcodes that survive a series of selection experiments. Computational models have been deployed to learn the latent binding affinities that are correlated to the sequenced count data; however, this correlation is often obfuscated by various sources of noise introduced in its complicated data-generation process. In order to denoise DEL count data and screen for molecules with good binding affinity, computational models require the correct assumptions in their modeling structure to capture the correct signals underlying the data. Recent advances in DEL models have focused on probabilistic formulations of count data, but existing approaches have thus far been limited to only utilizing 2-D molecule-level representations. We introduce a new paradigm, DEL-Dock, that combines ligand-based descriptors with 3-D spatial information from docked protein-ligand complexes. 3-D spatial information allows our model to learn over the actual binding modality rather than using only structured-based information of the ligand. We show that our model is capable of effectively denoising DEL count data to predict molecule enrichment scores that are better correlated with experimental binding affinity measurements compared to prior works. Moreover, by learning over a collection of docked poses we demonstrate that our model, trained only on DEL data, implicitly learns to perform good docking pose selection without requiring external supervision from expensive-to-source protein crystal structures.
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We investigate a model for image/video quality assessment based on building a set of codevectors representing in a sense some basic properties of images, similar to well-known CORNIA model. We analyze the codebook building method and propose some modifications for it. Also the algorithm is investigated from the point of inference time reduction. Both natural and synthetic images are used for building codebooks and some analysis of synthetic images used for codebooks is provided. It is demonstrated the results on quality assessment may be improves with the use if synthetic images for codebook construction. We also demonstrate regimes of the algorithm in which real time execution on CPU is possible for sufficiently high correlations with mean opinion score (MOS). Various pooling strategies are considered as well as the problem of metric sensitivity to bitrate.
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Simultaneous localization and mapping (SLAM) is one of the key components of a control system that aims to ensure autonomous navigation of a mobile robot in unknown environments. In a variety of practical cases a robot might need to travel long distances in order to accomplish its mission. This requires long-term work of SLAM methods and building large maps. Consequently the computational burden (including high memory consumption for map storage) becomes a bottleneck. Indeed, state-of-the-art SLAM algorithms include specific techniques and optimizations to tackle this challenge, still their performance in long-term scenarios needs proper assessment. To this end, we perform an empirical evaluation of two widespread state-of-the-art RGB-D SLAM methods, suitable for long-term navigation, i.e. RTAB-Map and Voxgraph. We evaluate them in a large simulated indoor environment, consisting of corridors and halls, while varying the odometer noise for a more realistic setup. We provide both qualitative and quantitative analysis of both methods uncovering their strengths and weaknesses. We find that both methods build a high-quality map with low odometry noise but tend to fail with high odometry noise. Voxgraph has lower relative trajectory estimation error and memory consumption than RTAB-Map, while its absolute error is higher.
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This paper introduced key aspects of applying Machine Learning (ML) models, improved trading strategies, and the Quasi-Reversibility Method (QRM) to optimize stock option forecasting and trading results. It presented the findings of the follow-up project of the research "Application of Convolutional Neural Networks with Quasi-Reversibility Method Results for Option Forecasting". First, the project included an application of Recurrent Neural Networks (RNN) and Long Short-Term Memory (LSTM) networks to provide a novel way of predicting stock option trends. Additionally, it examined the dependence of the ML models by evaluating the experimental method of combining multiple ML models to improve prediction results and decision-making. Lastly, two improved trading strategies and simulated investing results were presented. The Binomial Asset Pricing Model with discrete time stochastic process analysis and portfolio hedging was applied and suggested an optimized investment expectation. These results can be utilized in real-life trading strategies to optimize stock option investment results based on historical data.
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在机器人研究中,在不平坦的地形中安全导航是一个重要的问题。在本文中,我们提出了一个2.5D导航系统,该系统包括高程图构建,路径规划和本地路径,随后避免了障碍。对于本地路径,我们使用模型预测路径积分(MPPI)控制方法。我们为MPPI提出了新的成本功能,以使其适应高程图和通过不平衡运动。我们在多个合成测试和具有不同类型的障碍物和粗糙表面的模拟环境中评估系统。
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多标签图像分类允许从给定图像预测一组标签。与多类分类不同,每个图像只有一个标签,此类设置适用于更广泛的应用程序。在这项工作中,我们重新审视了多标签分类的两种流行方法:基于变压器的头和标签关系信息信息图处理分支。尽管基于变压器的头被认为比基于图基的分支更好地取得了更好的结果,但我们认为,使用适当的训练策略,基于图形的方法可以证明精确度的较小,同时将计算资源减少到推理上。在我们的训练策略中,我们在角度空间中引入了其修饰作用,而不是非对称损失(ASL)(ASL),而不是非对称损失(ASL)。与二进制跨熵损失相比,它隐含地学习了每个班级单位超球的代理特征向量,从而提供更好的歧视能力。根据提出的损失和训练策略,我们在单个模态方法中获得SOTA结果,以广泛的多标签分类基准,例如MS-Coco,Pascal-Voc,Nus wide和Visual Genome 500。 OpenVino培训扩展https://github.com/openvinotoolkit/deep-object-reid/tree/tree/multilabel
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现代基于深度学习的系统的性能极大地取决于输入对象的质量。例如,对于模糊或损坏的输入,面部识别质量将较低。但是,在更复杂的情况下,很难预测输入质量对所得准确性的影响。我们提出了一种深度度量学习的方法,该方法允许直接估算不确定性,几乎没有额外的计算成本。开发的\ textit {scaleface}算法使用可训练的比例值,以修改嵌入式空间中的相似性。这些依赖于输入的量表值代表了对识别结果的信心的度量,从而允许估计不确定性。我们提供了有关面部识别任务的全面实验,这些实验表明与其他不确定性感知的面部识别方法相比,比例表面的表现出色。我们还将结果扩展到了文本到图像检索的任务,表明所提出的方法以显着的利润击败了竞争对手。
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This paper presents a novel way to apply mathematical finance and machine learning (ML) to forecast stock options prices. Following results from the paper Quasi-Reversibility Method and Neural Network Machine Learning to Solution of Black-Scholes Equations (appeared on the AMS Contemporary Mathematics journal), we create and evaluate new empirical mathematical models for the Black-Scholes equation to analyze data for 92,846 companies. We solve the Black-Scholes (BS) equation forwards in time as an ill-posed inverse problem, using the Quasi-Reversibility Method (QRM), to predict option price for the future one day. For each company, we have 13 elements including stock and option daily prices, volatility, minimizer, etc. Because the market is so complicated that there exists no perfect model, we apply ML to train algorithms to make the best prediction. The current stage of research combines QRM with Convolutional Neural Networks (CNN), which learn information across a large number of data points simultaneously. We implement CNN to generate new results by validating and testing on sample market data. We test different ways of applying CNN and compare our CNN models with previous models to see if achieving a higher profit rate is possible.
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数字媒体(例如,照片,视频)可以轻松创建,编辑和共享。编辑数字媒体的工具能够这样做,同时还可以保持高度的照片现实主义。尽管数字媒体的许多类型的编辑通常是良性的,但其他类型的编辑也可以用于恶意目的。例如,最先进的面部编辑工具和软件可以人为地使一个人在不合时宜的时间里微笑,或者将权威人物描绘成虚弱和疲倦的人以抹黑个人。鉴于越来越容易编辑数字媒体和滥用的潜在风险,因此媒体取证已经大大努力。为此,我们创建了一个编辑的面部图像的挑战数据集,以帮助研究社区开发新的方法来解决和对数字媒体的真实性进行分类。我们的数据集包括应用于受控的,肖像式的额叶脸部图像和全场景图像的编辑,这些图像可能包括每个图像的多个(即多个)脸部。我们数据集的目标是解决以下挑战问题:(1)我们可以确定给定图像的真实性(编辑检测)吗? (2)如果已经编辑了图像,我们可以\ textit {entimize}编辑区域吗? (3)如果已经编辑了图像,我们可以推论(分类)执行哪种编辑类型?图像取证中的大多数研究通常试图回答项目(1),检测。据我们所知,没有专门策划的正式数据集分别评估项目(2)和(3),本地化和分类。我们的希望是,我们准备好的评估协议将帮助研究人员改善与这些挑战有关的图像取证中最新的。
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尺寸不正确的气球导管可能导致手术后并发症增加,但是即使术前成像,正确的选择仍然是一个挑战。在手术过程中反馈有限,很难验证正确的部署。我们建议使用集成的阻抗测量和电阻抗断层扫描(EIT)成像来评估气球的变形并确定周围腔的大小和形状。以前使用单个阻抗测量值或压力数据和分析模型的工作,同时证明了较高的尺寸精度,已经假设了圆形横截面。在这里,我们通过添加多种电极来检测椭圆形和遮挡的管腔并获得EIT图像以定位变形来扩展这些方法。以14 FR(5.3 mm)导管为例,进行数值模拟,以找到两个相距10 mm的8个电极的两个环的最佳电极构型。模拟预测,可检测到的最大纵横比在30mm时从14mm气球的0.9降低到0.5。实验验证了尺寸和椭圆度检测结果。构建了原型机器人气球导管,以自动膨胀一个兼容的气球,同时记录EIT和压力数据。在复制具有椭圆形和不对称曲线的狭窄血管的实验中收集了数据,并在血管成形术期间的管腔扩大。校准后,该系统能够正确定位闭合和检测为0.75的宽高比。 EIT图像进一步定位了阻塞,并在气球充气期间可视化管腔扩张。
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